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 Table of Contents    
LETTER TO THE EDITOR  
Year : 2018  |  Volume : 52  |  Issue : 6  |  Page : 682-683
Author's reply


1 Department of Orthopaedic, Hospital Pulau Pinang, 10990 Georgetown, Penang, Malaysia
2 Department of Orthopaedic Surgery, Universiti Malaya Medical Center, Jalan Universiti, Kuala Lumpur, Malaysia
3 Department of Pathology, Hospital Pulau Pinang, 10990 Georgetown, Penang, Malaysia

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Date of Web Publication5-Nov-2018
 

How to cite this article:
Narhari P, Haseeb A, Lee S, Singh VA. Author's reply. Indian J Orthop 2018;52:682-3

How to cite this URL:
Narhari P, Haseeb A, Lee S, Singh VA. Author's reply. Indian J Orthop [serial online] 2018 [cited 2018 Dec 11];52:682-3. Available from: http://www.ijoonline.com/text.asp?2018/52/6/682/244972
Sir,

I am pleased that you[1] have shown keen interest in my manuscript.[2] However, points that got my attention are as follows: (1) This case was a spontaneous transformation of a chondroblastoma (benign) to conventional osteosarcoma (malignant) in a healthy adult. The patient did not have any signs or symptoms to suggest that he was immunocompromised. I suggest some clarification to be done to emphasize that the case was a healthy adult. (2) Osteosarcomas are never associated with HIV in the past. I believe that there is no justification to screen the patient for HIV or performing a CD4 count in this patient. Even if it was done and happens to be positive, it would probably mean a mere coincidence rather than clinical association between HIV and osteosarcoma. (3) Considering point (2) above, please consider to revise the statement below: HIV infection ought to be considered in the studied patient and, hence, CD4 count and viral overload estimations were solicited to be contemplated. If these measurements were done and they showed positive HIV status, the case in question could be truly considered a novel case report. This is because osteosarcoma transformation of a chondroblastoma in HIV-positive patient has never been reported in the literature so far.

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Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Al-Mendalawi MD. Spontaneous conventional osteosarcoma transformation of a chondroblastoma: A case report and literature review. Indian J Orthop 2018;52:682.  Back to cited text no. 1
  [Full text]  
2.
Narhari P, Haseeb A, Lee S, Singh VA. Spontaneous conventional osteosarcoma transformation of a chondroblastoma: A case report and literature review. Indian J Orthop 2018;52:87-90.  Back to cited text no. 2
[PUBMED]  [Full text]  

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Correspondence Address:
Dr Prashant Narhari
Orthopaedic Oncology Unit, Penang General Hospital, 10990 Georgetown, Penang
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ortho.IJOrtho_141_18

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