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ORIGINAL ARTICLE
Year : 2016  |  Volume : 50  |  Issue : 4  |  Page : 421-426

N-terminal telopeptides of type I collagen and bone mineral density for early diagnosis of nonunion: An experimental study in rabbits


1 Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province; Department of Orthopedic Surgery, Hainan Provincial People's Hospital, Haikou 570311, Hainan Province, China
2 Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
3 Department of Orthopedic Surgery, Hainan Provincial People's Hospital, Haikou 570311, Hainan Province, China

Correspondence Address:
Zhan-Jun Shi
Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5413.185608

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Background: The diagnosis and treatment of bone nonunion have been studied extensively. Diagnosis and treatment of nonunion are mainly performed based on the interpretation of clinico-radiographic findings, which depend on the clinician's experience and the degree of bone callus formation during the fracture-healing process. However, resolution may be compromised when the bone mineral content is <25%. A feasible method of monitoring bone-healing is therefore needed. We monitored a rabbit model of bone nonunion by regular radiographic examinations, QCT detection, and biomarker concentrations. Materials and Methods: Twenty purebred New Zealand rabbits (10 male and 10 female, 5-6 months of age, 2.5-3.0 kg) were divided into bone defect Group (I) that 10 left radius bones underwent resection of 1.5 cm of mid-radius bone and bone fracture Group (II) that another 10 left radius bones underwent only mid-radius fracture. Quantitative computed tomography detection of bone mineral density (BMD) and serum markers of bone formation (osteocalcin [OC], bone-specific alkaline phosphatase) and bone resorption (C- and N-terminal telopeptides of type I collagen (NTX) and tartrate-resistant acid phosphatase 5b) were assayed. There are twenty rabbits (10 male and 10 females). The age was 5-6 months weighing 2.5-3.0 kg). The defect was created in middle 1/3 radius in 10 rabbits and fracture was created in middle 1/3 radius of 10 rabbits. Results: BMD and NTX concentrations were significantly lower at 5 weeks postoperatively compared to the preoperative values and were significantly different between the two groups. OC showed no significant difference before and after surgery. Conclusions: BMD and NTX concentrations may be useful for early detection of bone nonunion in rabbits.


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