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CASE REPORT
Year : 2014  |  Volume : 48  |  Issue : 5  |  Page : 533-535

Klebsiella pneumoniae carrying blaNDM-1 gene in orthopedic practice


1 Department of Microbiology, Government Medical College Hospital, Sector 32, Chandigarh, India
2 Department of Orthopedics, Government Medical College Hospital, Sector 32, Chandigarh, India

Correspondence Address:
Varsha Gupta
Department of Microbiology, Government Medical College Hospital, Sector 32 B, Chandigarh - 160 030
India
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Source of Support: Department of Microbiology, Government Medical College Hospital, Chandigarh, Conflict of Interest: None


DOI: 10.4103/0019-5413.139888

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Emergence and spread of carbapenemases in Enterobacteriaceae is a cause of concern worldwide, the latest threat being New Delhi metallo-β-lactamase (NDM-1). This report is of an orthopedic case with fracture femur managed with internal fixation and bone grafting, who subsequently developed secondary infection with Klebsiella pneumoniae harboring blaNDM-1 gene. Minimum inhibitory concentration (MIC) of imipenem was ≥8 μg/ml by E-test, suggestive of carbapenemase production. Phenotypic and further genotypic detection confirmed the presence of blaNDM-1 gene. The isolate remained susceptible only to tigecycline, colistin, and polymyxin B.


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