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ORIGINAL ARTICLE
Year : 2013  |  Volume : 47  |  Issue : 6  |  Page : 540-546

Bone morphogenetic protein-7 accelerates fracture healing in osteoporotic rats


1 Orthopaedic Research Institute; Department of Orthopaedic Surgery, St. George Hospital Clinical School, University of New South Wales, Kogarah, New South Wales, Australia
2 Department of Orthopaedic Surgery, St. George Hospital Clinical School, University of New South Wales, Kogarah, New South Wales, Australia
3 Orthopaedic Research Institute, St. George Hospital Clinical School, University of New South Wales, Kogarah, New South Wales, Australia

Correspondence Address:
Ashish D Diwan
Orthopaedic Research Institute and Department of Orthopaedic Surgery, St. George Hospital Sydney, Kogarah, New South Wales 2217
Australia
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Source of Support: The authors acknowledge that a research fellowship supported by Stryker Australia was provided to AL. OP-1 test material was provided gratis by Stryker Biotech (MA)—now Olympus Biotech. Spine Service and the University of New South Wales provided funds for the animal studies and the South Eastern Illawara Health Service, NSW, provided the remainder of the funding for this work,, Conflict of Interest: None


DOI: 10.4103/0019-5413.121569

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Background: Osteoporosis is characterized by low bone mass, bone fragility and increased susceptibility to fracture. Fracture healing in osteoporosis is delayed and rates of implant failure are high with few biological treatment options available. This study aimed to determine whether a single dose of bone morphogenetic protein-7 (BMP-7) in a collagen/carboxy-methyl cellulose (CMC) composite enhanced fracture healing in an osteoporotic rat model. Materials and Methods: An open femoral midshaft osteotomy was performed in female rats 3 months post-ovarectomy. Rats were randomized to receive either BMP-7 composite ( n = 30) or composite alone ( n = 30) at the fracture site during surgery. Thereafter calluses were collected on days 12, 20 and 31. Callus cross-sectional area, bone mineral density, biomechanical stiffness and maximum torque, radiographic bony union and histological callus maturity were evaluated at each time point. Results: There were statistically significant increases in bone mineral density and callus cross-section area at all time points in the BMP-7 group as compared to controls and biomechanical readings showed stronger bones at day 31 in the BMP-7 group. Histological and radiographic evaluation indicated significant acceleration of bony union in the BMP-7 group as compared to controls. Conclusion: This study demonstrated that BMP-7 accelerates fracture healing in an oestrogen-deficient environment in a rat femoral fracture healing model to scientific relevance level I. The use of BMP-7 composite could offer orthopedic surgeons an advantage over oestrogen therapy, enhancing osteoporotic fracture healing with a single, locally applied dose at the time of surgery, potentially overcoming delays in healing caused by the osteoporotic state.


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