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REVIEW ARTICLE
Year : 2010  |  Volume : 44  |  Issue : 4  |  Page : 363-368

Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts


Department of Pathology, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel, Mumbai, Maharashtra, India

Correspondence Address:
Nirmala A Jambhekar
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai-400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5413.69304

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Ewing's sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing's sarcoma/PNET and discusses their clinical and therapeutic implications.


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