Neurobionplus
Home About Journal AHEAD OF PRINT Current Issue Back Issues Instructions Submission Search Subscribe Blog    
Login 

Users Online: 3908 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
 


 
LETTER TO EDITOR Table of Contents   
Year : 2010  |  Volume : 44  |  Issue : 1  |  Page : 112
Nonsecretory multiple myeloma, how to make a diagnosis?


Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand

Click here for correspondence address and email

Date of Web Publication31-Dec-2009
 

How to cite this article:
Wiwanitkit V. Nonsecretory multiple myeloma, how to make a diagnosis?. Indian J Orthop 2010;44:112

How to cite this URL:
Wiwanitkit V. Nonsecretory multiple myeloma, how to make a diagnosis?. Indian J Orthop [serial online] 2010 [cited 2019 Dec 11];44:112. Available from: http://www.ijoonline.com/text.asp?2010/44/1/112/58615
Editor,

I read the recent case report on nonsecretory multiple myeloma with a great interest. [1] Middela et al. noted that nonsecretory multiple myeloma is a case with diagnostic dilemma and "a high index of suspicion must be borne in mind when excluding multiple myeloma as a cause of pain, pathological fracture or lytic lesion". [1] Indeed, it is accepted that diagnosis of nonsecretory multiple myeloma is very difficult. In this case, although there are some soft signs showing myeloma nature (decreased normal immunoglobulin and lytic bone lesion), the lack of abnormal secreted protein brings the diagnostic difficulty. Recently, the new laboratory technique for detecting of low level of abnormal secreted protein has been developed and can be the new hope in the fast and easy diagnosis of nonsecretory multiple myeloma. The "Freelite™ test" is an example. This test helps determine low level of abnormal free light chain and has been accepted as the new tool for diagnosis of non secretory multiple myeloma. [2],[3]



 
   References Top

1.Middela S, Kanse P. Nonsecretory multiple myeloma. Indian J Orthop 2009;43:408-11.  Back to cited text no. 1  [PUBMED]  Medknow Journal  
2.Jung S, Kim M, Lim J, Kim Y, Han K, Min CK, et al. Serum free light chains for diagnosis and follow-up of multiple myeloma. Korean J Lab Med 2008;28:169-73.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Pratt G. The evolving use of serum free light chain assays in haematology. Br J Haematol 2008;141:413-22.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  

Top
Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160
Thailand
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5413.58615

Rights and Permissions




 

Top
 
 
  Search
 
   
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    References
 

 Article Access Statistics
    Viewed2558    
    Printed87    
    Emailed1    
    PDF Downloaded150    
    Comments [Add]    

Recommend this journal