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Year : 2006  |  Volume : 40  |  Issue : 1  |  Page : 41-45

Relationship between vitamin D insufficiency in osteoporosis and blood bone biochemistry

Department of Orthopaedics, Dayanand Medical College and Hospital Ludhiana, India

Correspondence Address:
Sameer Batra
Department of Orthopaedics, Flat 9, Llys Miaren, Ysbyty Gwynedd, (NW Wales NHS trust), Bangor, United Kingdom LL57 2PW.

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Source of Support: None, Conflict of Interest: None

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Background: Vitamin D insufficiency is associated with increased PTH secretion, which in turn leads to bone resorption. Method : In the present study primary involution osteoporosis and vitamin D 3 levels were studied in 62 subjects including thirty one controls. The biochemical analysis of serum calcium, phosphorus, ALP, albumin and vitamin D3 [1,25 (OlH) 2 D 3 ] levels was done and 1,25 (OlH) 2 D 3 levels were significantly decreased in osteoporotic patients when compared to non-osteoporotic control group. Results : There was a significant correlation of magnitude of sun exposure and vitamin D intake in the diet with 1,25 (OH) 2 D 3 levels. However, no correlation could be obtained between vitamin D3 levels with increasing age. Our results significantly demonstrated that assays for routinely used bone biochemistry parameters including serum calcium, phosphate, parathormone and alkaline phosphatase are not representative of hypovitaminosis D even in those whose serum PTH is elevated and only reliable way to confirm this is to do vitamin D levels. Conclusion : The diagnosis of hypovitaminosis D should be made on the basis of clinical suspicion, arising from an awareness of risk factors, leading to direct measurements of serum vitamin D.

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