Thromboprophylaxis by dalteparin sodium in elective major orthopaedic surgery - A multicentric Indian study
Department Of Orthopaedics,St. John's Medical College, Bangalore, India
N Rajagopalan Professor and Head of the Dept. Of Orthopaedics,St. John's Medical College, Bangalore - 560034. India
Source of Support: None, Conflict of Interest: None
Post-operative deep vein thrombo-embolic disease is a serious and frequent complication after major orthopaedic surgery. A multi-centric prospective study was undertaken in 105 patients with major orthopedic surgery to evaluate the thromboprophylatic efficacy and safety of dalteparin sodium in the prevention of deep vein thrombosis. The age of enrolled patients were 58.1 ± 17.1 years. Dalteparin Sodium 5000 IU SC once a day was given upto 6±1 days. Colour Doppler ultrasound was performed on all patients on post-operative 6±1 day. Deep venous thrombosis (DVT) was diagnosed in 8 (7.8%) patients. No patient developed pulmonary embolism. Dalteparin Sodium offers an effective, safe and easily administered prophylaxis against DVT.