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A total of 40 patients undergoing total knee arthroplasty were divided in two groups i.e. simultaneously operated for bout knees and those getting single knee arthroplasty in same sitting, there was a significant (p<0.05) drop in Mean Arterial Pressure and CVP from their basal value. In the arterial blood gases analysis fall in the Pa02 values was recorded after each knee surgery. But there was no change in PaC02 and Sa02 in either group after tourniquet deflation.