Home About Journal AHEAD OF PRINT Current Issue Back Issues Instructions Submission Search Subscribe Blog    

Users Online: 2986 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Year : 2000  |  Volume : 34  |  Issue : 4  |  Page : 224-230

Topical Cyclophosphamide In The Treatment Of Bone And Joint Infection

Correspondence Address:
S. K Gupta

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

From 1974 to 1999. 35 patients with intractable pyogenic and tuberculosis infection of bone and joint were treated by combining local instillation of Cyclophosphamide (CPM) to standard conventional treatment. Topical CPM was first used in 1974 in a 22 year old male to treat tuberculosis of hip which became secondarily infected with Staph aureus following an arthrotomy. With instillation of CPM through a sinus lead to stoppage of discharge within a week and satisfactory progress of healing. Such serendipitous favourable result prompted us to use topical CPM in 34 other patients with intractable bone and joint infection. Healing occurred in 28 (80%) patients. Amongst the 7 patients who did not respond fully, one patient required disarticulation of the shoulder and another patient required removal of a total knee prosthesis. Remaining 5 patients are still under treatment.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal