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Twenty cases of bone grafts in humans were studied by fine needle aspiration cytology from the perigraft area at intervals of 10, 20, 30 and 40 days. Ten patients received autogenous bone grafts while the other ten were recipients of allogenic bone implants (0.6M HCI treated partially decalcified bone). The paramenters observed were: mean lymphocyte counts, CD4+ / CD8+ cell counts and CD4+ / CD8+ cell ratios. There was a gradual increase in the relative lymphocyte count and CD8+ lymphocytes while decrease in the CD4+ / CD8+ lymphocyte ratios from 10th to 40th day. A similar trend was observed in fresh autogenous bone graft and allografts. The CD4+ / CD8+ ratios were higher in allografts as compared to autografts on all the days. The partially decalcified alloimplants seen to excite immunocellular response almost similar to that of fresh autogenous grafts. Thus partially decalcified allografts are a good substitute of autogenous bone grafts in clinical practice.