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The effect of acetyl salicyclic acid on fracture healing was studied experimentally. Standard experimental fractures were produced in the femora of 18 rabbits of either sex and nearly equal weight. They were divided into two groups control and experimental of 9 each. Acetyl salicyclic acid was given to experimental group in dose of 14.2 mg/kg/day. Fracture healing was studied, after sacrificing animals on the 21st or 42nd day, under four parameters of clinical, radiological, mechanical and histological. The fracture line was found to be visible at 42nd day in experimental group while consolidation was observed in control groups. Bending strength was more in control group. Histologically also at 42nd day the control group showed abundance of newly formed bone with marked osteoblastic activity and remodeling as compared to the experimental group. This study established that acetyl salicyclic acid inhibited fracture healing.