Source of Support: None, Conflict of Interest: None
The present study was undertaken to evaluate association of HLA class-I antigens in Indians at Varanasi to understand Rheumatoid-SSA overlap. A total of thirty five cases of seronegative spondyloarthritides (SSA),. ninty cases of Rheumatoid Arthritis (RA) and one hundred random unrelated healthy controls were analysed. A highly significant increase in risk for developing SSA was observed in HLA-B27 positive cases (RR-80.83, P<0.0001). It was absent in RA patients. Thus this study brings out that the clinically difficult RA-SSA overlap cases can be clarified by HLA-B27 typing along with other investigations.