Source of Support: None, Conflict of Interest: None
A controlled clinical trial of short-term regimens of rifampicin and isoniazid given daily for 6 (Amb 6) or 9 (Amb 9) months in ambulant patients was compared with a group of patients who had radical anterior resection and bone graft with the same drugs given for six months (Rad 6). 304 patients were studied. After exclusions, the results of 260 patients at 3 years are reported. The methodology, the management, the complications and the results are described. The results indicate that ambulatory short-term regimens for 6 or preferably 9 months with rifampicin and isoniazid taken daily is the treatment of choice with a favourable status of 82 per cent of the Rad 6,93 per cent of the Amb 6 and 97 per cent of the Amb 9 patients respectively.