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Year : 1985  |  Volume : 19  |  Issue : 1  |  Page : 47-52

Role Of Defattened, Decalcified Xenograft, Composited With Autologous Bone Marrow In Bridging Large Osteoperiosteal Gaps In Rabbits



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S. V Sharma


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Role of defattened, decalcified xenografts composited with fresh autologous marrow in bridging large osteoperiosteal defects (1 to 1.5cm) in the rabbit’s ulna is presented. Xenografts were obtained by sacrificing guinea pigs and from the routine orthopaedic operations on human beings. The bone grafts were defattened in acetone, decalcified in 0.6 N HCI for 18 to 36 hrs for partial decalcification and for 48 to72 hrs for full decalcification, and preserved in ethanol. There was no clinical, radiological and histological evidence of neo-osteogenesis at the host graft junctions. However, all the graft showed histological evidence of formation of woven bone and active marrow elements in all the experimental animals of both the partially and fully decalcified groups. It is felt that the autologous marrow does induce neo-osteogenesis. However, being a xenograft, it is probably the antigenecity of the graft which inhibits the formation of adequate quantum of lamellar bone. Further studies on the role of xenografts may prove beneficial for the future.


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