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Year : 1981  |  Volume : 15  |  Issue : 2  |  Page : 153-156

Serum And Synovial Fluid Alpha-I-Antitrypsin Levels In Cases Of Rheumatoid Arthritis

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N Kishore

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Various protease inhibitors found in serum are alpha-I-antitrypsin, alpha-2-macroglobulin, inter-alpha-I trypsin inhibitor and alpha-I-antichymotrypsin (Schwick et al. 1966); alpha-I-antitrypsin (alpha-I-AT) is the main trypsin inhibitor. Its 90 per cent inhibiting capacity remains in alpha-I-globulin and rest in alpha-2 band. It not only inhibits trypsin but many other proteolytic enzymes like thrombin, plasmin, collagenase, leucocytase etc. (Lieberman 1973). Cochrane (1968) first suggested that synovial cells and leucocytes liberate Iysosomal enzymes, which cause damage of the joint in rheumatoid arthritis. Swedlund et al. (1974) found increased level of alpha-I-AT in cases of rheumatoid arthritis, while Walsh and McConkey (1977) observed deficient levels of antitrypsin in cases of rheumatoid arthritis. This study was undertaken to measure serum and synovial fluid alpha-I-AT in cases of rheumatoid arthritis.

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