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Various changes in serum proteins may occur due to joint disorders, while synovial fluid proteins are often affected by systemic diseases. Hunder and Gleich (1974) described the raised serum and synovial proteins in cases of rheumatoid arthritis. Inamdar et al. (1974) reported the changes in other fractions of glycoproteins in synovial fluid. The present study was carried out to observe the changes in proteins of serum and synovial fluid in different groups of chronic arthritis.