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Year : 1980  |  Volume : 14  |  Issue : 1  |  Page : 72-77

Effect Of Local Injection Of Staphylococcal Vaccine On Fracture Healing-An Experimental Study



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P Tejeswar Rao


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Infection has been criminated as a cause of delayed union and non-union of fractures. In some infected fractures, there is excess callus formation as compared to uninfected fractures due to the effect of low grade infection stimulating the reparative osteogenic cells to lay down more bone tissue. Similarly in case of chronic pyogenic osteomyelitis there is massive new bone formation probably due to some stimulus provided by the pyogenic organism, the nature of which is unknown. Starr (1947) has stated that “Infection is not all detriment and a certain amount of infection at the site of fracture stimulates new bone formation”. This has aroused interest in us to study the effect of local injection of staphylococcal vaccine at the fracture site. No relevant literature for a similar work done previously is available, expect of Sullivan (1961) who studied at effects of injection of live staphylococcus for obtaining interbody fusion of spine in dogs.


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