Source of Support: None, Conflict of Interest: None
Recent studies on zinc metabolism are suggestive of the fact that zinc sulphate not only enhances the healing o f wounds but also promotes fracture healing (Mesrobian and Shklar 1969, Westmoreland and Hoekstra 1969, McCray et al. 1972, Battistone et al. 1972, Calhoun et al. 1975). The uptake of zinc by fractured bone is increased during fracture healing (Calhoun and Smith 1968). Similarly other drugs like methandienone (Singh and Udupa1964) and ascorbic acid were also found to effect the rate of fracture healing. Therefore it was considered worthwhile to do a comparative study in zinc sulphate supplemented animals and in zinc sulphante, ascorbic acid and methandienone supplemented animals with non-supplemented controls with a view to find the rationale and the efficacy of these drugs in the healing of fracture.