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Year : 1978  |  Volume : 12  |  Issue : 1  |  Page : 76-80

Role Of Haem In Experimental Production Of Pigmented Villonodular Synovitis In Rhesus Monkeys



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V. P Bansal


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Pigmented villonodular synovitis is clinical entity introduced by Jaffe, Lichenstein and Sutro (1942). In its typical from the synovial membrane shows brownish pigmentation and is covered by villi and coarse nodular outgrowths. The villi and nodules are most numerous in the recesses of the joint, but may most of the synovial surface. The exact etiology of pigmented villonodular synovitis is not known. Jaffe et al. (1941) designated it an inflammatory lesion although no specific agent could be determined. Repeated haemorrhages into the joint due to trauma have also been ostulated as a possible etiological factor (Young and Hudacek 1954). Singh et al. (1969) from this institute produced typical villonodular synovitis experimentally in monkeys following injection of iron-dextrin and autogenous blood into the joints. The pre cent study was conducted in rhesus monkeys to elucidate which particular component of blood is responsible for producing such lesions, thus iron containing component of haemosideria i.e. haem was injected into the knee and ankle joints of these animals.


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