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Year : 1976  |  Volume : 10  |  Issue : 2  |  Page : 118-123

Suppressive Effect Of Cyclophosphamide On Ossification Of Lower Limb Bones In Rat Fetuses


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A. K Sanyal


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Cyclophosphamide has been shown to be teratogenic in several laboratory animals (Singh 1971, Singh and Gupta 1972). Its major action seems to be related to the inhibition of DNA synthesis especially affecting the mesenchymal tissue (Chaube et al. 1967 and Singh et al. 1971). Limb anomalies in rat fetuses are found to be most frequent when this drug is given during the 12th to 14th day of gestation (Singh and Sanyal 1972). The present report communicates the suppressive effect of cyclophosphamide on the ossification of lower limb bones in rat fetuses after single intraperitoneal injection in the pregnant rats on the 12th to 14th day of gestation.


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