Source of Support: None, Conflict of Interest: None
The hydroxyproline excreted in urine by healthy individuals when placed on meat and collagen free diet is derived mainly from the skeleton. The measurement of urinary hydroxyproline excretion provides a good index of the metabolic activity of the skeleton (Dull and Henneman 1963, Klein and Curtiss 1964). It has been shown to be raised in different conditions in which the skeleton is metabolically more active (Laitinen, Nikkila and Kivirikko 1966). Significantly higher excretion of hydroxyproline in urine in patients suffering from osteomalacia has been reported from our laboratory (Srivastava and Tandon 1973). The purpose of this study was to study the effect of treatment on the urinary hydroxyproline excretion in osteomalacic patients.