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Year : 1974  |  Volume : 8  |  Issue : 2  |  Page : 120-126

Urinary Excretion Of Acid Mucopolysaccharide in Normal Human Beings And Generalised Musculo-Skeletal Affections



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S. V Sharma


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Normal urine contains chondroitin sulphate-A and possibly chondroitin sulphate-C but it does not contain chondroitin sulphate-B. Dorfman and Lorincz (1957) reported increased quantities of chondroitin sulphate-B and small amounts of secondary mucopolysaccharides identified as heparin mono-sulphuric acid in the urine of patients who had the clinical picture of Hurler’s disease. Dorfman’s work was confirmed by Meyer and his associates (1958). This finding coupled with histological picture indicated that Hurler’s disease was caused by abnormal metabolism or storage of chondroitin sulphate-B. More recently Nagel (1965) reported observations on acid mucopolysaccharide excretion in the urine of 64 patients with abnormal enchondral bone formation and other skeletal abnormlities. He concluded that the excretion of acid mucopolysaccharide in most of the skeletal disorders was near or below the mean normal values in the urine except in cases of Hurler’s disease where it was found raised.


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