Source of Support: None, Conflict of Interest: None
The source and mechanism of new bone formation whenever two living bones come in contact was first investigated by Haller and Duhemel in the eighteenth century. It is now well known that all the elements of autograft and homograft died irrespective of whether they were transplanted with or without periosteum and the dead bone was gradually replaced and regenerated through osteoblasts from neighbouring living bone (creeping substitution). James Syme (1840) experimenting in Dogs concluded that periosteum was osteogenic in nature. Phemister (1930, 1947 suggested that osteogenesis in bone repair occurred mostly from inner layer of periosteum and from endosteum, and to a much lesser degree from bone cells lining the haversian system. Though a large volume of work has been done on the role of periosteum, and the fate of a graft, but there is very little information about the role which muscle action may play in relation to bone grafts and their incorporation. The present work was designed to investigate what role muscle action may have on bone-grafts.