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Year : 1974  |  Volume : 8  |  Issue : 1  |  Page : 68-76

Osteomalacia-A Clinico-Pathological Study


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T. P Srivastava


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The presence of excess of osteoid in osteomalacia was first described by Pommer in 1885. Since the differentiation between the mineralized and unmineralised bone could be best made out in undecalcified sections which were technically difficult to prepare, not much work could be done on this aspect of the disease till recent years. The development of newer techniques of preparing undecalcified bone sections (Duthie 1954, Woodruff and Norris 1956, Kropp 1956, Kelly, Peterson and Janes 1957, Frost 1958) and of special stains for demonstration of ostecid (meyer 1956, Frost 1959, Sissons and Aga 1970) have enabled workers to undertake detailed histological study of the disease. The use of polarized light microscopy (Meyer 1956, Byers 1962, Frost 1962, Wood, Morgan, Peterson and Grossman 1968) and tetracycline labeling techniques (Muzzi 1960, Frost and Villaneuva 1960, Frost 1962) have provided additional tools for histological study of this disease. We have studied 31 cases of osteomalacia by light microscopy of undecalcified sections. Polarised light microscopic studies also have been done in some cases.


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