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Year : 1968  |  Volume : 2  |  Issue : 1  |  Page : 102-107

Immuno-Electrophoretic Study Of Antigenicity Of Bone Proteins



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P Chandra


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The problem of antigenicity of bone is a comparatively recent field of study. Through there is evidence in the literature that foreign bone tissue is antigenic and is rejected by immune phenomenon, there still remains a doubt about the capacity of bone tissue to produce circulating antibodies. A number of procedures evolved to demonstrate the presence of serum antibodies in response to transplantation of various tissues generally failed due to various reasons, chief among them being the fact that histocompatibility antigens are insoluble and most of these techniques required antigens to be in the soluble from (Siegrist and Enneking 1960, Aoike and Iiji 1960). However, a number of workers reported successful attempts and demonstrated serum antibodies in response to various tissue transplantations by various procedures like haemaggultination, cytotoxicity, leukagglutination, lymphogglutination, mixed agglutination, antiglobulin consumption test (Amos 1953, Terasaki, Cannon and Longmire 1959, Abeyounis, Milgrom and witebsky 1964, McDonald, Milgrom and Witebsky 1964, McDonald, Milgrom, Abeyounis and Witebsky 1965). The present study was undertaken to determine the antigenicity of bone by demonstrating serum antibodies, employing double diffusion technique of ouchterlony (1949) and the immuno-electrophoretic technique of Garbar (1959), after repeated injections of human, calf pigeon, frog and fish bone extracts in rabbits.


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